Harris County Sheriff's deputies say the crash happened just after 2:30 a.m. near Loch Katrine Lane.
Video from the scene shows the destroyed BMW split in half after a colliding with a Hummer.
Deputies say a 15-year-old passenger in the back seat of the BMW was killed. The driver and another passenger are in the hospital.
Family on the scene says the teen was a star football player at his high school in north Texas, and he was planning to transfer to a Houston-area school.
The driver of the Hummer was not seriously injured, officials say.
Authorities believe the Hummer driver was under the influence, and say he's been charged with driving while intoxicated.
Harris County District Attorney's Office Vehicular Crimes Chief Sean Teare says the Hummer driver could face additional charges pending a blood test.